Saturday, July 19, 2008

DNA yang ada, sudah lama?

Dna sudah lama? pelik ni.. aku tengok CSI.. satu kali diambil.. selamanya digunakan.. mungkin ada perlunya wikipedia dibuka..

maksud sudah lama itu.. mutasikah?
Existing DNA sample too old, says PM
vs
Expert: Specimen can be conserved for years
PM: DNA yang ada, sudah lama - Malaysiakini
PM DATUK SERI ABDULLAH SAYS DNA SPECIMEN OBSOLETE BUT FORENSIC EXPERTS SAY CAN BE CONSERVED FOR YEARS
To DNA, or not to DNA, that is the Question

http://en.wikipedia.org/wiki/DNA
'DNA can be damaged by many different sorts of mutagens, which change the DNA sequence. Mutagens include oxidizing agents, alkylating agents and also high-energy electromagnetic radiation such as ultraviolet light and X-rays. The type of DNA damage produced depends on the type of mutagen. For example, UV light can damage DNA by producing thymine dimers, which are cross-links between pyrimidine bases.[45] On the other hand, oxidants such as free radicals or hydrogen peroxide produce multiple forms of damage, including base modifications, particularly of guanosine, and double-strand breaks.[46] In each human cell, about 500 bases suffer oxidative damage per day.[47][48] Of these oxidative lesions, the most dangerous are double-strand breaks, as these are difficult to repair and can produce point mutations, insertions and deletions from the DNA sequence, as well as chromosomal translocations.[49]

Many mutagens fit into the space between two adjacent base pairs, this is called intercalating. Most intercalators are aromatic and planar molecules, and include ethidium, daunomycin, doxorubicin and thalidomide. In order for an intercalator to fit between base pairs, the bases must separate, distorting the DNA strands by unwinding of the double helix. This inhibits both transcription and DNA replication, causing toxicity and mutations. As a result, DNA intercalators are often carcinogens, and benzopyrene diol epoxide, acridines, aflatoxin and ethidium bromide are well-known examples.[50][51][52] Nevertheless, due to their ability to inhibit DNA transcription and replication, these toxins are also used in chemotherapy to inhibit rapidly-growing cancer cells.[53]'

1 Comment and put their link:

abeming said...

huhu...da lama x singgah...apa habaq kawan...

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